Bone Bioengineering Laboratory is developing innovative technology in microstructural assessments, biomechanical modeling, multiscale and mechanobiological approaches in skeletal research. Bone Bioengineering has both basic science and clinical significances in many medical fields, such as osteoporosis, osteoarthritis, or intervertebral disc degenerations. I will highlight our development of a three-dimensional imaging analysis and modeling technique for trabecular bone microstructure, its applications in basic science research of bone mechanics, and clinical applications in osteoporosis and osteoarthritis. We will discuss bone microstructural phenotypes in difference races and their implications in genetic and precision medicine. In parallel to these developments, we will also discuss our multiscale mechanobiological approaches in understanding the mechanisms of how bone senses and responds to mechanical loading and showcase some recent findings in mechanical regulation of bone formation. Finally, microstructure, mechanics, and mechanobiology of bone converge in anthropology evolution of human skeletons.

报告人简介：X. Edward Guo, Chair and Stanley Dicker Professor of Biomedical Engineering, Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York. Dr. Guo received his B.S. in applied mechanics from Peking University. He went to the U.S.A in 1988 and received his M.S. in 1990 and Ph.D. in 1994 in Medical Engineering and Medical Physics from Harvard University-MIT. In 1994-1996, Professor Guo did his postdoctoral fellowship in the Orthopaedic Research Laboratories at the University of Michigan at Ann Arbor with Professor Steven A. Goldstein in orthopaedic bioengineering. In 1996 he joined the Department of Mechanical Engineering and then Department of Biomedical Engineering at Columbia University as an Assistant Professor. He was promoted to Associate Professor with tenure in 2003, Professor in 2007, and named as Stanley Dicker Professor in 2018. He directs the Bone Bioengineering Laboratory in the Department of Biomedical Engineering at Columbia focusing his research interests in micromechanics of bone tissue,