题目：纳米毒理学——新需求、新学科

      Nanotoxicology – a new Discipline with Specific Demands

主讲人：Prof. Harald. F. Krug [Empa - Swiss Federal Laboratories for Materials Science and Technology, Switzerland]

报告摘要：

Nanosafety considerations become a substantial part of many funding programs, international conferences, and regulatory activities worldwide. Since the term “Nanotoxicology” appeared the first time within a title of a publication in 2004 confusion about its implementation and the objectives starts. One year later, the relationship to the former research on ultrafine particles has been highlighted and the “new discipline” started its success story. Whereas the number of publications regarding nanotoxicological issues from that time increases dramatically each year (from around 150 in 2004 to more than 3000 in 2013) clarity about possible risks dropped.

Besides the fact that the number of products containing nanoparticles (NP) is steadily increasing and thus all these have to be tested to be safe for the customer there is no general opinion how to approach this target. Whereas most of the OECD-guidelines can be used for testing nanomaterials, it has been demonstrated that biological screening methods are not all adapted for NP and therefore the results are often false-positive or false-negative. Not only we could demonstrate the interference of NP with the assay systems which often is neglected, solvent problems have not been addressed carefully and the appropriate controls are frequently missing as well as the needed characterization of the materials tested.

Taking all these critical points into account especially nanotoxicology has to establish a new strategy in the future as has been postulated last year. Recently, we made some very important recommendations which should lead to more detailed and reliable information about the biological activity of specific nanomaterials and we started with international round robins to establish a testing platform for nanomaterials

Harald. F. Krug教授简介：

Harald F. Krug is member of the board of directors and head of the research focus area “Health&Performance“ at Empa (St. Gallen) in Switzerland. He is appointed as “Titularprofessor” at the University of Berne since August 2008. His work is focused on applications and implications of new materials, especially nanomaterials. Special emphasis lays on the development of new biological models and the establishing of reliable and valid methods for the testing of nanoparticles and nanomaterials. His work was awarded in 2006 with the cwi-Award of the German Ceramic Society and in 2007 with the Research Award for “Alternatives for Animal Testing“ of the State Parliament of Baden-Württemberg.

Until 2009 he was the speaker of the “NanoCare“ consortium (2006-2009) and actually his former lab is involved in 5 EU-funded projects as well as more than 10 further projects funded by different national and international funding agencies. Additionally, he is founder member of the International Alliance for Nano-EHS-Harmonization (IANH) which is engaged in the evaluation of methods for nanomaterials testing. He consults the ministries of three different European countries and is member of various advisory boards of international projects and well-known institutes.