报告题目：超小碳基纳米材料的制备及其在纳米医学中的应用研究

Title: Toward applicable nanomedicine: the dawn of ultra-small carbon nanomaterials

报告人：马宇飞 （中国科学院苏州纳米技术与纳米仿生研究所，博士）

报告时间：2015-4-1 10：30

报告地点：校本部E楼202会议室

报告摘要：

近年来，碳基纳米材料在生物成像、药物递送、光热或光动力治疗、抗菌或免疫等生物医学领域的研究中备受关注，但他们的广泛应用一直受其胶体稳定性差和生物毒性不明确等因素的制约。减小纳米颗粒的尺寸是提高碳基纳米材料的生物相容性的重要策略之一。本报告将围绕超小尺寸的碳基纳米材料的制备和理化性质，从其合成方法、荧光和光热性质、生物毒性和客体载体等方面，介绍近年来在超小碳基纳米材料的生物医学（生物成像、光热治疗、免疫和抗菌等）应用领域所做出的努力。此外，还将介绍如何利用自组装技术解决超小碳纳米材料在载药率低和血液循环时间短等方面的不足，并发展出构建多功能载药系统的通用策略。

Abstract:

Carbon-based nanomaterials has drawn increasing attention recently in the field of bioimaging, drug delivery, photothermal or photodynamic therapy, anti-bacteria and immunity, but their wide applications have been handicapped by their poor physiological stability and uncertain biocompatibility. Reducing the size of a nanoparticle represents an important strategy to improve its biocompatibility. In this talk, it will be presented the recent efforts of the synthesis and biomedical applications of ultra-small carbon nanomaterials, which covers the in vitro and in vivo toxicity, bioimaging, photothermal therapy, vaccine adjuvant and anti-bacteria according to various physicochemical properties of the carbon nanomaterials. In addition, the advantages of self-assembly technique will be demonstrated, for the construction of multifunctional drug delivery systems to solve the problems of low payload and short blood circulation time of the ultra-small carbon nanomaterials.